As of the 2010 census, our population was 9,375. Our county seat is Belzoni. The county is named for Benjamin G. Humphreys. Humphreys County is Mississippi's newest county, having been formed in 1918. Humphreys County is located in the Mississippi Delta region.

We were named 'Farm-Raised Catfish Capital of the World' in 1976 by then Governor Cliff Finch, since we produced more farm-raised catfish than any other U.S. county. Forty thousand acres (160 square kilometers) of the county are underwater and used to grow catfish. About 60% of U.S. farm-raised catfish is raised within a 65-mile (105 km) radius of the county seat, Belzoni.